Aging
Principal investigator: Dr. Anton J.M. Roks, Assistant Professor
Vascular aging is a pathophysiological process that is increasingly threatening healthy aging in humans. In our research we focus on various aspects of vascular aging to battle this healthcare problem:
exploration of the role of genome damage, a main causative mechanism of aging
identification of markers
identification of affected signaling mechanisms
development of interventions
To efficiently address these issues we have dedicated preclinical models of accelerated vascular aging and techniques to explore cardiovascular function. Collaboration with consortia that investigate cardiovascular disease in large human cohorts allows us to verify the role of newly identified mechanism involved in vascular aging in humans. This approach enables us to add a strongly translational value to our preclinical models. Our studies are performed in collaboration with the strongest groups worldwide in the field of preclinical and clinical research on aging.
Companies we collaborate with:
Lanthiopharma
Tarix Pharmaceuticals
Unilever
References
- Wu H, Roks AJ. Genomic instability and vascular aging: A focus on nucleotide excision repair. Trends Cardiovasc Med 2014;24:61-8.
- Wu H, Roks AJ, Leijten FP, Garrelds IM, Musterd-Bhaggoe UM, van den Bogaerdt AJ, de Maat MP, Simoons ML, Danser AH, Oeseburg H. Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease. Clin Sci 2014;126:441-9.
- Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ. Nucleotide excision DNA repair is associated with age-related vascular dysfunction. Circulation 2012;126:468-78.
- Botden IP, Oeseburg H, Durik M, Leijten FP, Van Vark-Van Der Zee LC, Musterd-Bhaggoe UM, Garrelds IM, Seynhaeve AL, Langendonk JG, Sijbrands EJ, Danser AH, Roks AJ. Red wine extract protects against oxidative-stress-induced endothelial senescence. Clin Sci 2012;123:499-507.
- Oeseburg H, Iusuf D, van der Harst P, van Gilst WH, Henning RH, Roks AJ. Bradykinin protects against oxidative stress-induced endothelial cell senescence. Hypertension 2009;53:417-22.
To efficiently address these issues we have dedicated preclinical models of accelerated vascular aging and techniques to explore cardiovascular function. Collaboration with consortia that investigate cardiovascular disease in large human cohorts allows us to verify the role of newly identified mechanism involved in vascular aging in humans. This approach enables us to add a strongly translational value to our preclinical models. Our studies are performed in collaboration with the strongest groups worldwide in the field of preclinical and clinical research on aging.
Companies we collaborate with:
References
- Wu H, Roks AJ. Genomic instability and vascular aging: A focus on nucleotide excision repair. Trends Cardiovasc Med 2014;24:61-8.
- Wu H, Roks AJ, Leijten FP, Garrelds IM, Musterd-Bhaggoe UM, van den Bogaerdt AJ, de Maat MP, Simoons ML, Danser AH, Oeseburg H. Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease. Clin Sci 2014;126:441-9.
- Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ. Nucleotide excision DNA repair is associated with age-related vascular dysfunction. Circulation 2012;126:468-78.
- Botden IP, Oeseburg H, Durik M, Leijten FP, Van Vark-Van Der Zee LC, Musterd-Bhaggoe UM, Garrelds IM, Seynhaeve AL, Langendonk JG, Sijbrands EJ, Danser AH, Roks AJ. Red wine extract protects against oxidative-stress-induced endothelial senescence. Clin Sci 2012;123:499-507.
- Oeseburg H, Iusuf D, van der Harst P, van Gilst WH, Henning RH, Roks AJ. Bradykinin protects against oxidative stress-induced endothelial cell senescence. Hypertension 2009;53:417-22.
